In the multivariate Cox regression analysis (Table 4), the following characteristics were tested for disease specific survival and overall survival: tumor size, nodal status, histological grading, smoking, alcohol intake, Tregs count, CD8+/Tregs ratio, counts of CD3+, CD4+, CD8+, CD4+, CD3−CD56+CD16+ (NK cells), and CD19 (B cells), and recurrence. The gene discussed is CD8A; the disease is neoplasm.