While similar tumor suppressor effects of WT-ANXA7 and p53 in DU145 were accompanied by similar RB-E2F profiles, the lack of RB1 dephosphorylation and E2F induction by p53 compared to WT-ANXA7 contributed to the p53 insufficiency in androgen-sensitive LNCaP [4]. This evidence concerns the gene RB1 and neoplasm.