BSHX alleviates glomerulosclerosis and tubulointerstitial injury and subsequently reverses renal failure in 5/6 nephrectomy rats, possibly via inhibition of the inflammatory responses mediated by TNF-α, NF-κB, TGF-β1, CTGF, PPARγ, and OPN. The gene discussed is CCN2; the disease is glomerulosclerosis.