In conclusion, BSHX reduces the levels of Scr and BUN, inhibits in situ expression of FN and LN, increases the mRNA expression of PPARγ, and decreases the mRNA expression of TNF-α, NF-κB, OPN, TGF-β1, and CTGF in the kidney tissue of rats with chronic renal failure. This evidence concerns the gene CCN2 and chronic kidney disease.