TNF and rheumatoid arthritis: In RA patients with high disease activity levels of inflammatory markers (ESR, hsCRP, TNF-α, IL-6), fibrinogen, sE-selectin, ADMA, and ADMA/SDMA ratio were significantly higher than in those with a low disease activity, whereas concentrations of sVCAM-1, vWf, and PTX3 were significantly elevated in RA subjects with a low disease activity versus control subjects, exhibiting no significant further rises in those with a high disease activity.