However, OPG potentiates TNF-α-induced endothelial expression of VCAM-1, intercellular adhesion molecule-1 (ICAM-1), and E-selectin [27], which is in agreement with our observations, that is positive correlation between OPG and concentrations of sVCAM-1 and sE-selectin in RA patients, probably corresponding to endothelial activation. The gene discussed is TNF; the disease is rheumatoid arthritis.