It is noteworthy that, despite pronounced rises in hsCRP, TNF-α, and IL-6 in RA patients with a higher value of DAS28 compared to the remainder, we observed no significant differences in sVCAM-1, MCP-1, vWf, PTX3, and OPG, that is, putative markers of localized inflammation and endothelial activation, between subgroups of RA patients stratified according to DAS28. This evidence concerns the gene TNFRSF11B and rheumatoid arthritis.