Although Matsushita et al. associated high preoperative levels of sCXCL16 with liver recurrence and poor prognosis in colorectal cancer patients [11], little was known about the functions of TM-CXCL16 except that high expression of CXCL16 in cancer tissues correlated with favorable prognosis in renal and colorectal cancer patients [12, 13]. The gene discussed is CXCL16; the disease is cancer.