IL6 and colorectal carcinoma: Read studied 23 CRC stage IV patients referred to chemotherapy, and he observed a significant positive correlation between survival time and serum concentration of IL-10 (r = 0.488, p = 0.03) and a negative correlation between survival time and a concentration of IL-6 (r = −0.63, p = 0.003) (Read et al. 2007).