DYRK1A has been shown to suppress caspase-9-mediated apoptosis in mammalian cells through phosphorylation of caspase-9 on threonine residue 125.22, 23 These findings suggest that SAHA and DZNep induce DYRK1A-mediated apoptosis in cancer cells through activation of miR-1246. This evidence concerns the gene DYRK1A and cancer.