We have discovered that some miRNAs including miR-127 are regulated by epigenetic alterations such as DNA methylation and histone modification.12 DNA methylation inhibitors and HDAC inhibitors can activate epigenetically silenced tumor-suppressor miRNAs accompanied by downregulation of target oncogenes in human cancer cells.12, 13 However, the miRNA expression profiles altered by EZH2 inhibitors are still unknown. The gene discussed is EZH2; the disease is neoplasm.