EZH2 and cancer: As EZH2 has been reported to be essential for self-renewal of cancer stem cells,2 SAHA and DZNep, which inhibit EZH2, could be promising therapeutic agents for suppression of cancer stem cells.39, 40 After culture of AGS and HepG2 cells under anchorage-independent stem cell-specific conditions, spheroids were formed, as shown in Figure 2a.