As EZH2 is the catalytic subunit of polycomb repressive complex 2, which mediates epigenetic gene silencing by trimethylating histone H3 lysine 27, suppression of EZH2 by SAHA and DZNep may induce transcriptional activation of miR-1246, miR-302a and miR-4448 in cancer cells. The gene discussed is EZH2; the disease is cancer.