A recent study has shown that miR-1246 has a p53-responsive element in its promoter region, and that p53 induces miR-1246 expression in response to DNA damage.18 The results of the ChIP assay demonstrate that binding of p53 to the miR-1246 promoter region was significantly increased by treatment of cancer cells with SAHA and DZNep (Figure 6a). Here, TP53 is linked to cancer.