G6PD and neoplasm: Soon after this initial study, an independent group demonstrated that G6PD activity correlated with Gleason score.26 Subsequent studies have confirmed G6PD overexpression in different types of cancer.21, 22, 23, 29 Accordingly, silencing of G6PD has been reported to induce apoptosis,30 and increase ROS levels,31 while overexpression has been linked to enhanced tumor growth.32