Prostate cancer caused by the conditional knockout of floxed Pten in the prostate using probasin promoter-driven Cre expression, Pb-Cre;Ptenf/f (Pb-Pten), has been previously described.45 Following tamoxifen treatment, K8-CreERT2; Ptenf/f transgenic mice (K8-Pten) develop low-grade prostate intraepithelial neoplasia in 1 month and prostate cancer at 4–6 months.46, 47 In both the Pb-Pten (Figure 6a) and K8-Pten (Figure 6b) models, G6PD levels correlated with prostate cancer progression. Here, PTEN is linked to prostate intraepithelial neoplasia.