Recently, it was reported that one of 7 osteosarcoma cell lines, and one of 17 osteosarcomas harbored amplification of fibroblastic growth factor receptor 1 (FGFR1), a receptor tyrosine kinase located on chromosome 8p12, which leads to activation of the Ras/mitogen-activated protein kinase and PI3/Akt pathway, and ultimately leading to cell proliferation and differentiation 13. This evidence concerns the gene PI3 and osteosarcoma.