The biological significance of this genetic alteration was supported by inhibition of cell growth in the osteosarcoma cell line, G292, harboring the FGFR1 amplification, by the FGFR inhibitor, NVP-BGJ398, and was reinforced by cell growth suppression following silencing of FGFR1 using shRNAs 13. The gene discussed is FGFR1; the disease is osteosarcoma.