AGTR1 and essential hypertension, genetic: The genetic variation of RAS encoding genes, angiotensinogen (AGT), angiotensin-1-converting enzyme (ACE), and angiotensin II type 1 receptor (AGTR1), were associated with EHT and have been important genes for the association studies in various populations [8–10]. AGT, the natural substrate of RAS, is synthesized in the liver and released into blood circulation.