ACE and hypertensive disorder: Among the ACE gene polymorphisms of exon 17, G2350A variant has the most significant effect on plasma ACE concentrations as it accounts for 19% of the total variance in ACE plasma levels. ACE I/D is in linkage disequilibrium (LD) with ACE G2350A and both the variants are associated with essential hypertension with contradictory result [20, 21].