Therefore, the effective anti-tumor immune response induced by Lm-LLO-E7 is due to a number of factors such as reduced peripheral tolerance and increased maturation of dendritic cells but this response is only effective if tumors remain compliant through responsiveness to IFN-γ, a determinant that may be useful to predict patient outcomes with Lm-based immunotherapies. This evidence concerns the gene IFNG and neoplasm.