To determine the role of IFN-γ in the anti-tumor response mediated by Lm-LLO-E7, Dominiecki et al utilized a TC.1 variant cell line unresponsive to IFN-γ due to constitutive expression of a dominant negative form of the IFN-γ receptor, termed mugR (Dominiecki et al., 2005). The gene discussed is IFNG; the disease is neoplasm.