Support for this theory was found in a follow-up study demonstrating that autochthonous tumor formation in Her2/neu transgenic mouse after Lm-Flk-E1 or Lm-Flk-I1 vaccination correlated with the occurrence of mutations in Her2/neu CTL epitopes within those tumors (Seavey and Paterson, 2009). This evidence concerns the gene ERBB2 and neoplasm.