Currently, there are several antigens associated with tumor vascular endothelial cells with the most well characterized being the vascular endothelial growth factor (VEGF) and it's receptor (VEGFR) but others such as Cluster of Differentiation 105 (CD105) are also proving to be promising targets for Lm-based tumor immunotherapy (Goel and Mercurio, 2013). This evidence concerns the gene VEGFA and neoplasm.