In 1997, it was shown that the eis-1/pal-1/gfi-1/evi-5 locus serves as a target for M-MuLV proviral insertions in pre-B-cell lymphomas in Eμ-myc transgenic mice (20%) and in T-cell lymphomas in H2K-myc (75%) and Eμ-pim1 (93%) transgenic mice (25). Here, PIM1 is linked to T-cell non-Hodgkin lymphoma.