VCAN and neoplasm: Transcriptome analysis of microdissected tumor and stromal cells from OC specimens and TGF-β-treated normal ovarian fibroblasts recently identified versican as an upregulated gene in CAF, and versican expression was upregulated by TGF-β, with resulting activation of the NF-κB signaling pathway and increased levels of CD44, MMP-9, and the hyaluronan-mediated motility receptor (82).