The EpCAM (CD326) is a transmembrane glycoprotein expressed by particular epithelial cell types in healthy individuals; however, it is over-expressed in most carcinomas (21) and is a target in antibody-based therapies, e.g., trifunctional bispecific antibody catumaxomab was approved by the European Medicines Agency 2009 for the treatment of malignant ascites (21–23). Here, EPCAM is linked to carcinoma.