Given that (1) trastuzumab is associated with a low (0.4%) risk of heart failure when given in combination with docetaxel and carboplatin (Slamon et al. 2011), and (2) it is not known if adding bevacizumab to trastuzumab increases the risk of heart failure, our study included a HER2-positive cohort to gauge the cardiac safety of TCH plus bevacizumab. The gene discussed is ERBB2; the disease is heart failure.