Nonetheless, functional studies must be conducted to investigate the effects of the FOXI1 variant on SLC26A4 transcriptional activation and the impact of the two KCNJ10 variants on K+ channel conductance before a determination of the pathogenicity of these three variants and their effect on SNHL phenotypes can be more definitively made. Here, KCNJ10 is linked to sensorineural hearing loss disorder.