Some pathological factors in GAN, like neurofilament light chain (NF-L) and peripherin accumulation, are also hallmarks of many other diseases24 including Alexander disease (A×D), amyotrophic lateral sclerosis (ALS), Alzheimer’s disease, Parkinson’s disease, dementia with Lewy bodies, neuronal IF inclusion disease (NIFID), diabetic neuropathy, spinal muscular atrophy (SMA), and some forms of CMT (such as CMT 2E)20,25]. Here, NEFL is linked to early-onset autosomal dominant Alzheimer disease.