WEE1 and cancer: Several MD simulations were carried out at this scope, that were able to discriminate the dynamic and structural characteristics of Bcr-Abl and C-Abl kinases, this last responsible for the cardiotoxic effects; (3) systematic rigid body docking of potential inhibitors against 84 unique protein kinases identified three derivatives of indirubin (Zahler et al., 2007), one of which has been recently indicated as particularly active against cancer metastasis (Braig et al., 2013).