To this end, we analyzed the possibility to identify an alternative 9/10 mismatched donor for those HLA-C mismatched cases that had an increased probability of acute GVHD (i.e., PIRCHE-I > 0 and PIRCHE-II > 1, N = 17), using haplotype frequency tables (18). The gene discussed is HLA-C; the disease is acute graft versus host disease.