These data suggest that altered AR signaling and its effects on the downstream targets of calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2), which regulates the activity of a key energy sensor AMP-activated protein kinase (AMPK), promotes the metabolic switch that provides the energy for prostate cancer growth and progression (Massie et al., 2011). The gene discussed is AR; the disease is prostate cancer.