SREBF1 and neoplasm: These data suggest a divergent role of lipid production in prostate tumors: SREBP-1 dependent up-regulation of fatty acids production for phospholipid and membrane synthesis and signaling molecules that are essential for tumor progression (Currie et al., 2013; Soga, 2013); or SREBP-1-independent elevation of neutral and inactive lipid accumulation which restricts energy expenditure and limits tumor growth.