In addition, this cluster is a well-validated target for c-Myc, which itself is a direct target of VDR (Simpson et al., 1987; O'Donnell et al., 2005), and a recent report has proposed a regulatory role for the miR-17/92 cluster on PPARα levels, linking miR-17/92 to energy metabolism in prostate cancer cells (Wang et al., 2013). Here, MYC is linked to Familial prostate cancer.