Such functional interactions between nuclear receptors and TFs, including the antagonistic interaction between RARs and AR and PPARδ (Rivera-Gonzalez et al., 2012; Kittler et al., 2013), and the agonistic interaction between VDR and AR (Wang et al., 2011) provide valuable information that can be used to improve cancer prevention and therapy. The gene discussed is VDR; the disease is cancer.