These data suggest that altered AR signaling and its effects on the downstream targets of calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2), which regulates the activity of a key energy sensor AMP-activated protein kinase (AMPK), promotes the metabolic switch that provides the energy for prostate cancer growth and progression (Massie et al., 2011). This evidence concerns the gene AR and prostate carcinoma.