Exploiting leukemia cell models with differential responsiveness toward 1α25(OH)2D3 triggered-differentiation (Tagliafico et al., 2006) identified that certain VDR transcriptional targets could distinguish the aggressiveness of the leukemia, again, focused around cell cycle and included MS4A3 which can modulate the phosphorylation of CDK2 and therefore exert control over the cell cycle. The gene discussed is CDK2; the disease is leukemia.