We and others have previously shown that anti-inflammatory therapies or treatment with antibodies targeting adhesion molecules, including VCAM-1, E-selectin, ICAM-1, P-selectin, α4β1, αVβ3, vWF, or PECAM-1, inhibit vaso-occlusion in SCD mice (Kaul et al., 2004; Belcher et al., 2005, 2006, 2010b, 2013, 2014). Here, PECAM1 is linked to Schnyder corneal dystrophy.