MAPT and Alzheimer disease: Aging is the required paramount condition (Herrup, 2010) on which, in addition to Aβ together with tau deregulation, genes, chronic inflammation, mitochondrial, metabolic dysfunctions, impaired insulin signaling, oxidative stress, aberrant cell cycle reentry, cholesterol dysmetabolism as well as metal ion dyshomeostasis must synergistically work to promote AD pathological manifestation (Herrup, 2010; Querfurth and Laferla, 2010; Roberts et al., 2012).