MAPT and Alzheimer disease: In AD, aluminum seems to act as an effective cross-linker between tau phospho-sites, to “freeze” Aβ in its toxic oligomeric state, and to induce exposure of Aβ hydrophobic clusters aggregates, thereby boosting toxic properties of these misfolded proteins (Zatta et al., 2009; Bolognin et al., 2011; Chen et al., 2011; Granzotto et al., 2011).