Interestingly, the AChE inhibitor galantamine, used in the treatment of AD, has been shown to cause a reduction in basal delayed rectifier K+ currents in hippocampal neurons (Pan et al., 2003; Vicente et al., 2010), likely arising from Kv2.1 channels (Zhang et al., 2004b). The gene discussed is KCNB1; the disease is Alzheimer disease.