RTN4RL2 and Anxiety: In the open field test, NgR2−/− showed a significant increase in exploratory behavior compared to NgR2+/+ and NgR2+/−, as measured by the number of entries [F(2, 33) = 6.03, p = 0.01, Figure 3C] and time [F(2, 33) = 4.18, p = 0.02, Figure 3D] spent in the aversive center area, which is usually thought to reflect reduced anxiety (Miyakawa et al., 2001).