Undoubtedly, tau hyperphosphorylation is an important phenomenon in AD and other tauopathies and parallels the appearance of tau aggregates and NFTs, but despite great efforts, the underlying mechanisms that ultimately lead to toxicity and neurodegeneration remain elusive (Papanikolopoulou et al., 2010; Ambegaokar and Jackson, 2011). Here, MAPT is linked to Alzheimer disease.