Genetically, FA is a complex disease where mutations in sixteen different genes (FANC-A, -B, -C, -D1/BRCA2, -D2, -E, -F, -G, -I, -J/BRIP1, -L –M, –N/PALB2, -O/RAD51C; -P/SLX4; -Q/ERCC4/XPF) have been reported (Bogliolo et al, 2013). The gene discussed is ERCC4; the disease is Friedreich ataxia.