Studies in Figs 2 and 4 showing the generation of nuclear FANCD2 foci and the chromosomal stability of gene-edited FA fibroblasts and iPSCs upon exposure to ICL drugs demonstrate that the specific targeting of FANCA in the AAVS1 locus has completely corrected the phenotype of FA-A fibroblasts and bona fide iPSCs. The gene discussed is FANCD2; the disease is Friedreich ataxia.