Given the observation that the PLAD is dispensable for signal activation, the data also indicate that targeting the PLAD in RANK as a potential therapeutic for osteoporosis may not be as effective as initially predicted, as highlighted by the limited inhibitory effect of the small peptide (KGDIIVVYVSQT) on the formation of osteoclasts (Taguchi et al. 2012). This evidence concerns the gene TNFRSF11A and osteoporosis.