Indeed, half of the dozen predicted miR-142-3p targets encode for pivotal actin cytoskeleton-associated proteins, including Cofilin-2 (Cfl2), Glucocorticoid receptor DNA binding factor 1 (Grlf1), Biorientation of chromosomes in cell division 1 (Bod1), Integrin alpha V (Itgav), Twinfilin-1 (Twf1), and Wiskott–Aldrich syndrome-like (Wasl). This evidence concerns the gene WASL and Down syndrome.