‘Pan’-histone demethylase inhibitors 80 and 81 (Fig. 13) targeting both KDM1 and JmjC KDMs were synthesised in an effort to address the observation that both KDM1 and KDM4 are coexpressed and colocalise with the androgen receptor in prostate cancer [152]. The gene discussed is KDM1A; the disease is Familial prostate cancer.