[16] for review). A DOT1L KMT inhibitor is in clinical development for MLL-rearranged leukaemia [22]. A KMT EZH2 inhibitor [23] is being targeted at non-Hodgkin lymphoma [24]. Together, with the clinical use of DNA methyltransferase inhibitors [25], these studies validate the modulation of chromatin methylation status for cancer therapy. Here, EZH2 is linked to cancer.