Briefly, Libraty et al. [63] followed the mRNA expression levels of a T-cell associated gene (CD3e), a type 1 cytokine transcription factor (T-BET) and a type 2 cytokine transcription factor (GATA-3) in daily urine samples to identify risk factors for severe PUUV HFRS during acute illness (AKI). The gene discussed is GATA3; the disease is acute kidney injury.