SNX14 and Intellectual disability: It is interesting to speculate that the neurodevelopmental delay and intellectual disability observed in patients with a hemizygous deletion of 6q14 [23] might be caused by haploinsufficiency of SNX14, as there is currently no evidence that SNX14 is imprinted in humans and we found that ∼60% knockdown of Snx14 in mouse neurons produced dramatic phenotypic changes in neuronal intrinsic excitability and neurotransmission.