IL12B and Behcet disease: In the second stage, the frequencies of the rs3212227/IL-12B genotype CC and C allele were also significantly higher in BD cases (pc = 3.5×10−4, OR = 1.8, 95% CI 1.4 to 2.4; pc = 0.002, OR = 1.4, 95% CI 1.2 to 1.6, respectively) than that observed in the control group.