In the multiple linear regression analysis, including sex, age, BMI, HDL-C, LDL-C, hs-CRP, CHD and history of smoking, hypertension and/or diabetes, HDL-associated SAA was found to be independently associated with CHD (standardized β = 0.2, P = 0.004) and hs-CRP (standardized β = 0.6, P<0.001) in the total validation population, and not associated with any other factors. The gene discussed is SAA2; the disease is Hypertension.