Subsequently, while stratifying the Schizophrenia patient group based on the demographic variables, we report a strong association with de novo DNMTs. Among the de novo DNMTs in the present study, DNMT3B rs2424932 was strongly associated with gender and DNMT3B rs1569686 early age of onset while DNMT3L rs2070565 was found to be associated with family history and early age of onset. This evidence concerns the gene DNMT3L and schizophrenia.