LIMK1 and thyroid cancer: Indeed, we found that LIMK1 in all thyroid cancer cell lines (C643, XTC-1, FTC-133, and TPC-1) was inhibited with miR-20a overexpression, which suggests that the suppressive effect of miR-20a on cellular proliferation and invasion may be mediated by its effect on LIMK1. Indeed, direct knockdown of LIMK1 had the same effects on cellular invasion and migration as observed with the overexpression of miR-20a.