BACE1 and Alzheimer disease: Indeed, these miRNAs showed a role in the post-transcriptional regulation of β-secretase 1 (BACE1), an aspartic acid protease potentially important to the pathophysiology of AD [77], with evidences suggesting that high expression of BACE1 can give rise to inappropriate cleavage of APP and as a consequence to an increased load of amyloid β-peptides in patients with sporadic AD [78].