Moreover, it has been observed that serine palmitoyletransferase (SPT) directly regulates amyloid beta (Aβ) levels through the post-transcriptional regulation of miR-137, miR-181c, miR-9 and miR-29a/b, suggesting that SPT and the respective miRNAs are potential therapeutic targets for AD [39]. This evidence concerns the gene AGXT and Alzheimer disease.