FLT4 and neoplasm: The molecules that induce lymphatic vessel development, including members of the vascular endothelial growth factor (VEGF) family and their receptors (VEGF-A, VEGF-B, VEGF-C, VEGF-D, placental growth factor, VEGFR-1, VEGFR-2, and VEGFR-3), are associated with the angiogenesis induced by most cancer-cell types and certain tumor stromal cells [8,9,10,11].