MCT-1 (multiple copies in T-cell malignancy 1) oncogene stimulates Ras and AKT signaling function.26, 27, 28 Similar to PTEN,14 MCT-1 relocates from the cytoplasm to the nucleus upon genotoxicity.29 In support of MCT-1 oncogenic role in genomic instability, MCT-1 suppresses p53 activity and increases the frequency of massive chromosomal aberrations upon DNA damage.27,29 Depletion of p53 enhances the MCT-1 oncogenic effect on chromosomal destabilization, mitotic abnormality and tumor growth,27,28,30 implying an antagonism between p53 and MCT-1 in the neoplastic progression. The gene discussed is PTEN; the disease is neoplasm.