PTEN and breast cancer: Reduced p190RhoGAP is essential for the completion of cytokinesis, which hyperactive p190A and in turn impairs cytokinesis in the PTEN-null cancer cells.18 To investigate which p190RhoGAP was deregulated by MCT-1, the p190A and p190B mRNA levels were analyzed in the MDA-MB-468 breast cancer cells (Supplementary Figure S3).