AKT1 and leukemia: Moreover, treatment of leukemia HL 60 cells with different concentrations of 10AB diminished the expression of p-Akt (Ser473), p-PTEN (Ser380), Src, hexokinase II, and PKM 2, but enhanced the expression of p-ERK, p-38, p-JNK, and p-GSK 3β(Ser9) (Figure 3D).