ICAM1 and neoplasm: After this initial interaction, firm adhesion takes place, mediated by several cell adhesion molecules belonging to the integrin family [6] as well as the Intercellular Adhesion Molecule-1 (ICAM-1) and Vascular Cell Adhesion Molecule-1 (VCAM-1) from the immunoglobulin family, leading to tumor invasion [7], [8].