PFKM and hepatocellular carcinoma: Recently, Golinska et al. demonstrated that the cancer cells of hepatoma and of other hepatocellular carcinomas, even in the presence of a marked decrease in the inducible factor from hypoxia (HIF-1), independently of the modulation of gene expression and of mediated effects through proteomic mechanisms, significantly decrease the ATP levels and increase those of AMP [250]; these authors also present the stable retention of a stationary glycolytic state that is maintained through the allosteric effect of AMP on phosphofructokinase-1.