MBD2 and cancer: Although in the last 60 years cell biology has emphasized the genetic/epigenetic aspects that are linked to carcinogenesis and cancer, it has been clearly demonstrated in eukaryotes, both in simple organisms such as Saccharomyces cerevisiae, in other single-celled organisms and in metazoans, that the set of all of the metabolic reactions (metabolome) can significantly and strongly affect the level of expression of numerous genes through epigenetic mechanisms, such as the modulation of histone acetylation, cytosine methylation and also demethylase and deacetylase.