BDNF (Brain-derived neutrophic factor) expression was reported to show significantly increased expression in gastric cancer tissue compared to adjacent normal mucosa, and high levels of BDNF at the invasive front were correlated to vessel invasion, lymph node metastasis, peritoneal dissemination, and poor prognosis in gastric cancer patients [12]. Here, BDNF is linked to metastatic malignant neoplasm in the lymph nodes.