It shall also be noted that the morphological abnormalities of dendritic protrusions have been frequently associated with neuropsychiatric disorders, particularly those that involve cognitive deficits [7], [90], [91] and recent evidence implicates MMP-9 in aberrant synaptic plasticity and spine dysmorphology in neuropsychiatric disorders [92], [93], [94], [95]. This evidence concerns the gene MMP9 and Cognitive impairment.