PARP1 and cancer: In Table 3, a significant interaction between the pairwise-coding SNPs in XRCC1-PARP1 was found because subjects with the PARP1 Ala/Ala and XRCC1 Gln/Gln genotypes exhibited a higher risk of cancer compared with subjects carrying the PARP1 Val/Val and XRCC1 Arg/Arg genotypes (pooled OR = 3.53, 95% CI = 1.30–9.59).