SPAG5 and cervical carcinoma: Previously, we constructed a 1440 probe-customized oligonucleotide microarray and screened out 32 differentially expressed genes between PLNM-positive and PLNM-negative cervical cancer specimens.2 One of these genes, sperm-associated antigen 5 (SPAG5 or Astrin), was upregulated in PLNM-positive specimens compared with PLNM-negative specimens.