Recently, lncRNAs-mediated regulation on the expression of HOX gene family received increased attention in tumorigenesis and development.11, 23, 24 Many studies have shown that the HOX gene family were identified as classic modification targets of the polycomb complex during development, all four clusters were highly enriched in H3K27me3 marks.25 Moreover, large number of aberrant Hox gene expression have been found in various cancers.26 Next, we asked whether any of Hox genes were influenced by TUG1, thus participating in tumor progression. Here, TUG1 is linked to cancer.