These findings reinforce two key aspects in post-transplant therapeutics: the need to identify better biomarkers of transition from CsA-induced dysfunction to nephrotoxicity to improve clinical decisions and the molecular justification for early substitution of CsA by other less nephrotoxic immunosuppressive agents, being mTOR inhibitors the most suitable choice, in order to reduce the risk of chronic allograft nephropathy, thus improving outcomes in transplanted patients. Here, MTOR is linked to Crouzon syndrome-acanthosis nigricans syndrome.