MTOR and Nephropathy: The recognition of these serious adverse effects sparked interest in CsA-sparing strategies [10]: CsA avoidance is associated with high acute rejection rates and is not an option; dose reduction is associated with a modest improvement in renal function, but CsA-induced nephropathy is progressive over time when exposure is maintained; minimization protocols are the current preferred therapy, including the conversion from CsA to other drugs, specially to Sirolimus (SRL), an inhibitor of the mammalian target of rapamycin (mTOR) [11,12].