MTOR and Crouzon syndrome-acanthosis nigricans syndrome: Recently, Luo et al. [22] showed that rapamycin is less fibrogenic than CsA; thus, early detection of CsA-induced nephropathy and proper substitution for more adequate drugs, which seem to be the mTOR inhibitors, will greatly reduce the risk of chronic allograft nephropathy and improve the outcomes in transplanted patients.