Currently, there exists two major classes of EGFR targeted anti-cancer agents: (a) tyrosine kinase inhibitors (TKIs), such as Gefitinib and Erlotinib, which target the intracellular adenosine triphosphate (ATP) binding sites of the receptor; and (b) monoclonal antibodies against EGFR, most notably Cetuximab and Panitumumab, which target the extracellular ligand binding site of the receptor. This evidence concerns the gene EGFR and cancer.