In particular, the methylase EZH2 functions as an oncogene in different human cancers mainly through epigenetic silencing of tumor and metastasis suppressor genes, including E-cadherin [9], RUNX3 [10], SLIT2 [11], DAB2IP [12], FBXO32 [13], and KLF2 [14]. Here, EZH2 is linked to neoplasm.